Nature Immunology 2026
T Vatovec, AL Neehus, KJL Jackson, DT Avery, I Bagaric, L Erazo, CA Arango-Franco, M Ogishi, SF Ahmed, A Cederholm, AJ Russell, E Della Mina, D Al-Rifai, R Bull, L Buetow, S Sobrino, A Zhang, L Wahlster, M Michelet, N Parvaneh, J Peel, F Barzaghi, D Leardini, Q Philippot, F Saettini, J Dutrieux, B de Muylder, F Vendemini, F Baccelli, A Catala, E Gambineri, M Veltroni, V Pandiarajan, Y Aguilar, F Haerynck, M Elliott, S Turville, F Brillot, T Khan, F Consonni, L Berteloot, WA Sewell, G Rao, L Largeaud, F Conti, C Roullion, C Masson, F Pegoraro, T Ye, S Joubran, E Villalpando, B Bessot, Y Seeleuthner, T Le Voyer, J Rosain, H Li, Z Janda, E Muratore, C Soudee, E Delabesse, C Goulvestre, M Shahrooei, A Puel, I Andre, C Bole-Feysot, L Abel, M Erlacher, V Beziat, C Lagresle-Peyrou, R Cheynier, E Six, N Marr, M Pasquet, L Alsina, CC Goodnow, N Landegren, A Aiuti, P Zhang, R Masetti, DT Huang, CS Ma, JL Casanova, VG Sankaran, J Bustamante, SG Tangye, J Bohlen
Nature Immunology
Demonstrates that somatic CBL deficiency selectively impairs B cell development while sparing T cell function, revealing cell-type specific requirements for this E3 ubiquitin ligase.
Journal of Human Immunity 2026
Q Zhou, I Bagaric, F Komma, C Prakash, H Abolhassani, Z Chavoshzadeh, L Tsao, T Vatovec, C Soudee, J Rosain, DJ Minter, C Lu, N Al-Sukaiti, B Wu, J Sun, Q Zhang, JL Casanova, Q Pan-Hammarstrom, AY Chan, T Al-Farsi, X Wang, J Bustamante, J Bohlen
Journal of Human Immunity
Expands the genetic and clinical spectrum of X-linked MCTS1 deficiency by identifying four new patients with complete or partial forms, including the first hypomorphic MCTS1 variant.
Journal of Clinical Investigation 2024
J Bohlen, I Bagaric, T Vatovec, M Ogishi, SF Ahmed, A Cederholm, L Buetow, S Sobrino, C Le Floc'h, CA Arango-Franco, L Seabra, M Michelet, F Barzaghi, D Leardini, F Saettini, F Vendemini, F Baccelli, A Catala, E Gambineri, M Veltroni, Y Aguilar de la Red, GI Rice, F Consonni, L Berteloot, L Largeaud, F Conti, C Roullion, C Masson, B Bessot, Y Seeleuthner, T Le Voyer, D Rinchai, J Rosain, AL Neehus, L Erazo-Borrass, H Li, Z Janda, EJ Cho, E Muratore, C Soudee, C Laine, E Delabesse, C Goulvestre, CS Ma, A Puel, SG Tangye, I Andre, C Bole-Feysot, L Abel, M Erlacher, SY Zhang, V Beziat, C Lagresle-Peyrou, E Six, M Pasquet, L Alsina, A Aiuti, P Zhang, YJ Crow, N Landegren, R Masetti, DT Huang, JL Casanova, J Bustamante
Journal of Clinical Investigation
Reveals the molecular mechanism underlying autoinflammation in CBL-deficient patients, identifying constitutive ERK activation in monocytes as the driver of disease.
Cell 2023
J Bohlen, Q Zhou, Q Philippot, M Ogishi, D Rinchai, T Nieminen, S Seyedpour, N Parvaneh, N Rezaei, N Yazdanpanah, M Momenilandi, C Conil, AL Neehus, C Schmidt, CA Arango-Franco, T Le Voyer, T Khan, R Yang, J Puchan, L Erazo, M Roiuk, T Vatovec, Z Janda, I Bagaric, M Materna, A Gervais, H Li, J Rosain, JN Peel, Y Seeleuthner, JE Han, AS L'Honneur, M Moncada-Velez, M Martin-Fernandez, ME Horesh, T Kochetkov, M Schmidt, MA AlShehri, E Salo, H Saxen, G ElGhazali, A Yatim, C Soudee, F Sallusto, A Ensser, N Marr, P Zhang, D Bogunovic, A Cobat, M Shahrooei, V Beziat, L Abel, X Wang, S Boisson-Dupuis, AA Teleman, J Bustamante, Q Zhang, JL Casanova
Cell
Landmark discovery showing that MCTS1 is required for JAK2 translation in human immune cells, explaining why MCTS1-deficient patients are susceptible to mycobacterial infections.
Nucleic Acids Research 2023
J Bohlen, M Roiuk, M Neff, AA Teleman
Nucleic Acids Research
Identifies PRRC2 proteins as novel regulators of translation initiation that promote leaky scanning, expanding our understanding of start codon selection.
Nucleic Acids Research 2021
J Bohlen, M Roiuk, AA Teleman
Nucleic Acids Research
Demonstrates that rpS6 phosphorylation has transcript-specific effects on translation efficiency depending on ORF length, challenging the view of global translation regulation.
Nature Communications 2020
J Bohlen, L Harbrecht, S Blanco, KC von Hohenberg, K Fenzl, G Kramer, B Bukau, AA Teleman
Nature Communications
Establishes that DENR facilitates ribosome recycling after uORF translation, enabling reinitiation at main ORFs including the stress-response transcription factor ATF4.
Molecular Cell 2020
J Bohlen, K Fenzl, G Kramer, B Bukau, AA Teleman
Molecular Cell
Develops a novel method to track scanning 40S ribosomes, revealing that they remain tethered to the mRNA cap during scanning in human cells.
